ACS chemical neuroscienceAmyloid beta-PeptidesMicrogliaAsparagineAlzheimer DiseaseAnimals
Asparagine Deamidation Attenuates Toxicity, Aggregation, and Microglial Responses of Alzheimer's Amyloid-β.
Maria Sajimon, Christopher J Wheeler, Alejandro R Foley, Ka Chan, Martin N Griffin, Daniel M Dinakarapandian, Abigail Holberton, Jery Joy, Anant K Paravastu, Levi B Wood, Jevgenij A Raskatov
Published: 202510.1021/acschemneuro.5c00544
Abstract
Alzheimer's disease (AD) is a growing global challenge that imposes a tremendous burden on society and economies. Though recently approved anti-amyloid β (Aβ) immunotherapies show effectiveness in clearing amyloid and slowing cognitive decline, the r…
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