ACS chemical neuroscience
Synergistic Effect of Mutations in the Amyloidogenic Core of Human Amylin (hAM) Affords a New Potent Inhibitor of hAM Fibrillation: Computational Design and Experimental Validation.
Diksha Rani, Nitesh Priyadarshi, Deepti Goyal, Nitin Kumar Singhal, Bhupesh Goyal
Published: 202610.1021/acschemneuro.5c00433
Abstract
The human amylin, hAM, also known as the human islet amyloid polypeptide (hIAPP), fibrils are identified as a substantial risk element in type 2 diabetes (T2D). Thus, targeting hAM fibrillation could significantly influence the prevention and treatme…
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