ACS chemical neuroscienceAmyotrophic Lateral SclerosisSuperoxide Dismutase-1HumansMolecular Dynamics SimulationMutation
Understanding Structural Destabilization and Amyloid Aggregation in ALS-Related Neurodegenerative Disorder: An In Silico and Experimental Analysis of SOD1 Variants.
Nazanin Soleimanifard, Bagher Seyedalipour, Payam Baziyar, Saman Hosseinkhani
Published: 202510.1021/acschemneuro.5c00350
Abstract
Protein misfolding has been reported as a common symptom in many neurodegenerative diseases, leading to the formation of protein aggregates. Metal ions (holo form) are critical for the folding and function of WT-SOD1, whereas their absence (apo form)…
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