ACS chemical biology
TRIM9 and TRIM26 Interact with UBQLN2P497H to Modulate Its Proteasomal Degradation.
Xingyuan Chen, Zhongwen Cao, Xiaochen Liang, Ting Zhao, Yinsheng Wang
Published: 202610.1021/acschembio.5c00911
Abstract
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive motor neuron loss. ALS-linked mutations in UBQLN2 promote protein aggregation and disrupt proteostasis, yet the mutation-specific protein interacto…
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