ACS chemical biologyPeptidesSolid-Phase Synthesis TechniquesHumansMolecular ProbesCysteine Endopeptidases
Peptidic Probes to Capture Enzyme Activity Using Novel Solid Phase Compatible Warheads.
Valerio Cataldi, Nikita Ostrovitsa, Fangyuan Cao, Edward W Tate, Eoin M Scanlan, Joanna F McGouran
Published: 202610.1021/acschembio.5c00771
Abstract
Activity-Based Probes (ABPs) are invaluable tools for investigating enzymatic activity but can suffer from onerous syntheses and low stability in complex proteomes. Herein, we present the first synthesis of a robust, vinyl methyl ester (VME), bearing…
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