ACS chemical biologyOligopeptidesHumansProteasome Endopeptidase ComplexSingle-Cell AnalysisProteasome Inhibitors
Tellurophene-Tagged Carfilzomib Enables Single-Cell Mass Cytometric Mapping of Proteasome Activity.
Nicole Potter, Alexander Eddenden, Aleksandra Fomina, Anuroopa Dinesh, Hartland Warren Jackson, Alison P McGuigan, Michael Groll, Mark Nitz
Published: 202510.1021/acschembio.5c00691
Abstract
Tracking small-molecule distribution in heterogeneous cell samples at single-cell resolution remains a major analytical challenge. Here, we present a tellurophene-functionalized analogue of the proteasome inhibitor Carfilzomib (TeCar) whose distribut…
Preview only. Read the full abstract at the source