ACS chemical biology
Systematic Profiling of Peptide Substrate Specificity in N-Terminal Processing by Methionine Aminopeptidase Using mRNA Display and an Unnatural Methionine Analogue.
Raphael J Turra, Satoru Horiya, Mahesh Neralkar, Jennifer K Bailey, Timothy J Walsh, Viktor Horvath, Isaac J Krauss
Published: 202610.1021/acschembio.5c00680
Abstract
Methionine aminopeptidase (MAP) is useful in chemical biology research for the N-terminal processing of peptides and proteins and in medicine as a potential therapeutic target. These technologies can benefit from a precise understanding of the enzyme…
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