ACS chemical biologyDNARNANucleic AcidsNucleic Acid ConformationModels
Synthesis and Biophysical Properties of 3'-Deoxy-β-d-apio-d-furanosyl Nucleic Acids.
Victorio Jauregui-Matos, Dhrubajyoti Datta, Jayanta Kundu, Vathan Kumar, Joel M Harp, Adekunle Adebayo, Daniel Donnelly, Esau Medina, John C Chaput, Martin Egli, Muthiah Manoharan
Published: 202510.1021/acschembio.5c00591
Abstract
Inspired by the uncommon furanose configuration of 3'-deoxyapio-containing nucleic acids (apioNAs), we developed a facile and convenient synthesis of 24 building blocks of this modified nucleic acid monomer, including phosphoramidites, H-phosphonates…
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