ACS biomaterials science & engineering
CoCrMo Particles Drive Macrophage Ferroptosis via Inhibiting the Sirtuin 1/NRF2/GPX4 Pathway to Promote Periprosthetic Inflammatory Osteolysis.
Guangtao Fu, Jielong Zhou, Rongjie Wu, Jianling Su, Chuangran Wu, Bichun Zhang, Yu Xie, Qiujian Zheng, Yuanchen Ma
Published: 202610.1021/acsbiomaterials.5c01694
Abstract
Nanoscale wear particles generated over time in the implant-bone interface induce profound periprosthetic inflammatory osteolysis, the most common complication after total joint arthroplasty, while macrophages serve as key initiators of this response…
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