ACS biomaterials science & engineering
GPC3127-136-HSP70 mRNA Nanovaccine in Combination with Anti-PD-L1 Therapy Elicits Robust T-Cell-Mediated Immunity against Hepatocellular Carcinoma.
Peng Wang, Rui Dong, Mengjie Zhang, Jingyi Liao, Paiyu Liu, Bo Lei, Hongjuan Cui, Yanmeng Peng, Bing Ni
Published: 202610.1021/acsbiomaterials.5c01444
Abstract
Hepatocellular carcinoma (HCC) remains a clinically challenging malignancy, and it is imperative to develop novel therapeutic strategies for HCC treatment. In this study, we developed a novel mRNA-based nanovaccine (SK-mRNA) targeting the tumor-assoc…
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