ACS applied materials & interfacesNucleotidyltransferasesHumansMembrane ProteinsDNAAnimals
Biological Logic-Gated DNA Self-Assembly Strategy for Precision Tumor Imaging and Selective Activation of the cGAS-STING Pathway.
Yaru Cheng, Ran Chang, Zelin Guo, Zhuangqiang Gao, Huiting Lu, Haifeng Dong
Published: 202610.1021/acsami.5c22573
Abstract
The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway is a promising target for cancer immunotherapy, but conventional synthetic nucleic acids often cause nonspecific activation and systemic inflammation, limiting clinical t…
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