ACS applied materials & interfacesAnimalsDoxorubicinCardiomyopathiesMitochondrial DynamicsMice
Injectable Magnolol-Peptide Hydrogel as a Minimally Invasive Treatment for Doxorubicin-Induced Cardiomyopathy via Inhibition of Aberrant Mitochondrial Fission.
Yongquan Hua, Huiming Chen, Yuanyuan Wu, Yajie Wu, Chenyazhuo Hu, Yinghua Zeng, Mingzhi Shen, Jie Zhan, Rongsen Meng, Yanbin Cai
Published: 202610.1021/acsami.5c20219
Abstract
Doxorubicin (DOX), an effective anthracycline chemotherapeutic agent, faces clinical limitations due to dose-dependent cardiotoxicity that can progress to irreversible DOX-induced cardiomyopathy (DIC). This pathology is driven by mitochondrial dysfun…
Preview only. Read the full abstract at the source