ACS applied materials & interfacesFerroptosisHumansPorphyrinsAnimalsMetal-Organic Frameworks
Hypoxia-Activated Biodegradable Porphyrin-Based Covalent Organic Frameworks for Cancer Ferroptosis Therapy through Multiple Regulatory Pathways.
Yulong Liu, Jun Wang, Ziqi Wang, Kang Yang, Liqin Jiao, Xiaoqian Bu, Jun Ma, Hongfang Shao, Bin Song, Ruiping Zhang
Published: 202510.1021/acsami.5c18480
Abstract
Ferroptosis therapy efficacy in cancer is seriously restricted by the overexpression of glutathione (GSH) and hypoxia. Herein, a hypoxia-activated biodegradable porphyrin-based covalent organic framework (HPCOF) loading l-buthionine sulfoximine (BSO)…
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