ACS applied materials & interfacesCarcinomaNon-Small-Cell LungHumansLung NeoplasmsDeoxycytidine
Synergistic Proteolysis Targeting Chimera Chemotherapy Conjugate for Potent Non-small Cell Lung Cancer Treatment.
Qixin Zhao, Rui Zeng, Tao Bi, Xuemei Yang, Ting Wang, Lei Chen, Juan Huang, Xiyu Dai, Houping Xu, Qin Sun, Zengjin Liu
Published: 202510.1021/acsami.5c18202
Abstract
Nonsmall cell lung cancer (NSCLC) exhibits high malignancy, low survival rates, and unfavorable prognosis. As a primary chemotherapy agent for NSCLC, gemcitabine (GEM) suppresses RNA/DNA synthesis to trigger cancer cell apoptosis. Nevertheless, GEM t…
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