ACS applied materials & interfacesHumansGene EditingCRISPR-Cas SystemsMagnetite NanoparticlesPlasmids
Magnetically Driven High-Speed Rolling Nanoclusters for Enhanced CRISPR/Cas9 Genome Editing.
Huating Kong, Xia Liu, Kai Xia, Yong Guan, Jichao Zhang, Yu Zhang, Bingxin Liu, Zhilei Ge, Qian Li, Xiaolei Zuo, Lihua Wang, Jiang Li, Ying Zhu, Chunhai Fan
Published: 202510.1021/acsami.5c15498
Abstract
Despite the tremendous potential of the CRISPR/Cas9 gene-editing technology in precision therapeutics, intracellular delivery remains a major challenge. High cytoplasmic viscosity and lysosomal entrapment significantly impair the cytosolic transport…
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