ACS applied bio materials
Chelation-Controlled Oriented and Irreversible Immobilization of Native Antibodies on Photoreactive Magnetic Nanoparticles.
Yi-Ren Huo, Avijit K Adak, Sachin K Kawade, Yi-Ju Chen, Mira Anne C Dela Rosa, Yu-Ju Chen, Chun-Cheng Lin
Published: 202610.1021/acsabm.5c02168
Abstract
We present a strategy for the irreversible and oriented immobilization of native antibodies (Abs) onto magnetic nanoparticles (MNPs) by integrating Ni2+-NTA chelation with diazirine (Dia)-mediated photo-crosslinking. MNPs were co-functionalized with…
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