ACS applied bio materials
AFM-Based Single-Molecule Force Spectroscopy of PEG-Anti-PEG Antibody Interactions.
Glenn Villena Latag, Hiroyuki Tahara, Airi Katase, Shoichi Maeda, Yiwei Liu, Yoshimitsu Kakuta, Takamasa Teramoto, Takeshi Mori, Tomohiro Hayashi
Published: 202610.1021/acsabm.5c01967
Abstract
Poly(ethylene glycol) (PEG) is widely used as a stealth polymer to enhance drug stability and circulation by reducing immune recognition. However, anti-PEG antibodies are increasingly reported in humans, leading to accelerated drug clearance and adve…
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