ACS applied bio materialsMetforminAnimalsNLR FamilyPyrin Domain-Containing 3 ProteinMice
Metformin Nanodelivery System Alleviates Morphine-Induced Analgesic Tolerance via Inhibiting the TXNIP/NLRP3/GSDMD Axis.
Dandan Yao, Xintong Zhao, Yi Wang, Xiaohai Xu, Liang Cao, Tingting Sun, Ayang Zhao, Jing Chen
Published: 202510.1021/acsabm.5c01748
Abstract
Morphine-induced analgesic tolerance limits its clinical use. This study shows that metformin alleviates such tolerance by inhibiting the TXNIP/NLRP3/GSDMD axis, reducing microglial activation and proinflammatory cytokines in CD-1 mice (metformin 200…
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