Organic letters
HFIP-Mediated (3+2) Annulation of Bicyclobutanes with Indolyl Alcohols for Diastereoselective Access to Tetracyclic Spiroindolenines.
Shiksha Deswal, Akkattu T Biju
Published: 202610.1021/acs.orglett.5c05244
Abstract
Although bicyclo[2.1.1]hexanes (BCHs) have emerged as powerful bioisosteres of substituted benzenes, efficient methods for the synthesis of their spirocyclic variants remain limited. Herein, we disclose HFIP-mediated (3+2) annulation of bicyclo[1.1.0…
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