Organic letters
Organocatalytic Enantioselective Synthesis of Axially Chiral Tetrasubstituted Allenes via Direct 1,8-Addition to In Situ Formed Alkynyl 8-Methylenenaphthalen-2(8H)-ones.
Kaige Shen, Tian Liang, Yihao Zhang, Xinyan Ke, Shao-Fei Ni, Pengfei Li, Lixing Zhao, Wenjun Li
Published: 202610.1021/acs.orglett.5c05223
Abstract
Organocatalytic enantioselective construction of axially chiral tetrasubstituted allenes has been achieved from the reaction between α-(2-hydroxynaphthalen-8-yl)propargylic alcohols and 2-arylindoles for the first time. With the aid of a suitable chi…
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