Organic letters
Stereoselective Construction of C2-Symmetric Adjacent Bis-α,α'-cis-Disubstituted THF Skeleton via Double Intramolecular Amide Enolate Alkylation: Total Syntheses of (+)-Membranacin and (+)-Squamocin-N.
Srinivas Batthula, Sudharshan Reddy Sanapalli, Mallesham Samala, Chandrashekhar Rapelli, Minjung Kwak, Nageswarao Yalavarthi, Seok Ho Kim, Deukjoon Kim, Jongkook Lee
Published: 202610.1021/acs.orglett.5c05114
Abstract
Described herein is the highly stereoselective and concise first asymmetric total synthesis of (+)-squamocin-N (1b) bearing a C15-C24 adjacent bis-tetrahydrofuran (THF) backbone with threo/cis/threo/cis/threo stereochemistry. This approach features c…
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