Organic letters
Seeking Equality from an Asymmetric System: The Convergent Total Synthesis of Prostacyclin Drug (±)-Beraprost Sodium.
Xinyu Zhu, Zhihao Qi, Jingfan Pan, Sheng Jiang, Ting Wang, Taobin Chen, Tianyu Wang, Xiangyu Zhang
Published: 202610.1021/acs.orglett.5c05111
Abstract
(±)-Beraprost sodium is an oral prostacyclin drug used to treat pulmonary arterial hypertension (PAH). It exists as a mixture of two C-4 diastereomers in a ratio of approximately 1:1, which presents significant challenges for process development. Her…
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