Organic letters
Total Syntheses of Grandilodines A and C and Lapidilectam via a Photoredox-Catalyzed Decarboxylative (6 + 2) Radical Annulation.
Hao Wu, Bin Jiang, Zhaoxing Chen, Shuang Luo, Bin Lin, Peijun Liu, Xiaozu Liu
Published: 202610.1021/acs.orglett.5c05094
Abstract
Herein, a unified approach to the concise total syntheses of grandilodine A, grandilodine C, and lapidilectam is described. Key steps in this synthesis include a sequential reductive amination/lactamization to assemble the pyrrolidinone structure, a…
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