Organic letters
Base-Promoted [4 + 3] Cycloadditions Enabling the Construction of Polycycle-Fused Uracils from N-Aminoisoquinolinium Derivatives.
Wen-Rong Wu, Yuan-Jie Meng, Juan Chen, Zi-Feng Yang, Xin-Xing Liu, Xiang Liu, Pengju Feng, Shang-Shi Zhang
Published: 202610.1021/acs.orglett.5c04929
Abstract
As the sole nucleobase characteristic of RNA, uracil possesses a unique heterocyclic architecture that endows it with exceptional value as a privileged scaffold in medicinal chemistry. Herein, we report a versatile and efficient strategy for construc…
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