Organic letters
Exploring a Unique Class II Diterpene Cyclase: The Modified Catalytic Acid Motif Contributes to Ring Contraction in Premutilin Synthase.
Kristin Helwig, Jun Xie, Cody Lemke, Meimei Xu, Xinye Kang, Meirong Jia, Reuben J Peters
Published: 202610.1021/acs.orglett.5c04898
Abstract
The class II diterpene cyclase from pleuromutilin biosynthesis contains a unique variant of the otherwise highly conserved DxDD motif (DxDM), which cooperatively serves as the catalytic acid, and uniquely produces an "A" ring contracted product, muti…
Preview only. Read the full abstract at the source