Organic letters
(3 + 2) Annulation of Cyclopropanone Acetal with Silyl Enol Ether toward the Synthesis of Polysubstituted Cyclopentanones.
Yankun Zhao, Hongya Yan, Wang Xiang, Yufeng Lai, Zhirui Shi, Ling He, Min Zhang
Published: 202610.1021/acs.orglett.5c04864
Abstract
A (3 + 2) annulation to access the structurally diverse polysubtituted cyclopentanones bearing two adjacent quaternary stereogenic centers is reported. This reaction is proposed to proceed through a domino Mukaiyama aldol/homoaldol reaction of silyl…
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