Organic letters
Phosphine-Catalyzed Regio- and Stereoselective Umpolung Addition of Amides to Alkynoates: Access to Complex α,β-Dehydroamino Acid Derivatives.
Nicklas W Buchbinder, Kyle L Dunnavant, Andrew D Bage, Owen N Beck, Kaamia R Harris, Reilly K Gwinn, Webster L Santos
Published: 202610.1021/acs.orglett.5c04858
Abstract
Accessing complex α,β-dehydroamino acids remains challenging due to the instability of the enamine product during N-terminal deprotection. We report a mild, organocatalytic method for the installation of primary amides on the α-carbon of alkynoates t…
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