Organic letters
Pd-Catalyzed C-H/C-C Cascade Activation for the Synthesis of γ-Lactams.
Peng Zhang, Shihaozhi Wang, Shan Xu, Xue-Jing Zhang, Ming Yan
Published: 202610.1021/acs.orglett.5c04783
Abstract
This work establishes a palladium-catalyzed cascade reaction combining C(sp3)-H functionalization and C-C bond cleavage of cyclopropanes, enabling the direct and efficient construction of biologically relevant dihydro-2H-pyrrol-2-ones (γ-lactams) fro…
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