Organic lettersIsocyanatesMolecular StructureNucleoside Diphosphate Sugars
Modular Synthesis of Nucleoside Diphosphate Sugar Analogues Using Chlorosulfonyl Isocyanate and Dichlorophosphoryl Isocyanate.
Roy Steneker, Koen J Rijpkema, Tim P Ofman, Mert Sagiroglugil, Carme Rovira, Gijsbert A van der Marel, Dmitri V Filippov, Herman S Overkleeft, Jeroen D C Codée
Published: 202610.1021/acs.orglett.5c04568
Abstract
Pyrophosphates are central to biology, and synthetic pyrophosphate isosteres are widely sought to create biomimetic molecules to study diverse biochemical processes. We describe a flexible, modular synthesis of nucleoside diphosphate sugar analogues…
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