Organic letters
Copper/N-Heterocyclic Carbene Cooperatively Catalyzed Remote Asymmetric ε-Alkylation of Yne-Thiophene Esters with Enals.
Zhaoliang Ge, Su-Na Guan, Hao Xu
Published: 202510.1021/acs.orglett.5c04559
Abstract
A highly enantioselective Cu/NHC cooperative catalytic system was developed for the remote ε-alkylation of yne-thiophene esters with enals. The dual catalysis couples a chiral Cu-PyBox complex, which generates a reactive copper-vinylallenylidene inte…
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