Organic letters
Cobalt-Catalyzed Asymmetric 1,4-Reduction of α,β-Unsaturated Nitriles with HBpin.
Li Ma, Zhaolin Wang, Chenggong Zheng, Jialong Xv, Jiarui Tang, Yifei Chen, Qing Xu, Biao Cheng, Yuanzhi Xia, Yanshu Luo, Jianhui Chen
Published: 202510.1021/acs.orglett.5c04453
Abstract
A series of novel AAO ligands were synthesized and employed in the cobalt-catalyzed asymmetric 1,4-reduction of α,β-unsaturated nitriles with HBpin, affording β-stereogenic alkyl nitriles with high enantioselectivities. This protocol can be scaled to…
Preview only. Read the full abstract at the source