Organic letters
Enantioselective Access to Lactam-Fused Eight-Membered Bridged Biaryls via N-Heterocyclic Carbene-Catalyzed [5 + 3]-Domino Annulation.
Yuanyuan Cheng, Jing Li, Qijian Ni
Published: 202510.1021/acs.orglett.5c04452
Abstract
We disclose herein an efficient asymmetric synthesis of axially chiral lactam-fused bridged biaryls through an N-heterocyclic carbene-catalyzed [5 + 3] annulation of ortho-indolizinyl N-sulfonylanilines with α-bromoenals. This transformation proceeds…
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