Enantioselective Synthesis of Spiro-bis-N-heterocyclic Lactams via Formal (3+2) Cycloaddition of 3-Methylene Isoindolinones with C3-Substituted 2-Indolylmethanols.

A stereoselective formal (3+2) cycloaddition protocol between 3-methylene isoindolinones and C3-substituted 2-indolylmethanols has been developed. The reactions afforded a wide range of chiral spiro-bis-N-heterocyclic lactams bearing nonadjacent ster…

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