Organic lettersCytochrome P-450 Enzyme SystemHemiterpenesSesquiterpenes4-ButyrolactoneMolecular Structure
Biosynthesis of Trichobisabolins Involves a UbiA-Type Terpene Cyclase for trans-Zingiberenol Generation and a Single Cytochrome P450 Catalyzing the γ-Butenolide Formation from an Isoprene Unit.
Cheng Shen, Rui-Ting Guo, Lin Chen, Ya-Qian Li, Jie Chen, Man-Cheng Tang
Published: 202510.1021/acs.orglett.5c04272
Abstract
Through genome mining, a conserved biosynthetic gene cluster from the biocontrol Trichoderma species was identified and characterized to be responsible for the biosynthesis of γ-butenolide-containing sesquiterpenoid trichobisabolin B. The biosyntheti…
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