Organic lettersMolecular StructureStreptomycesDepsipeptidesCyclizationEsterification
Total Synthesis of WS9326B via a Bioinspired Macrolactonization Strategy.
Seung Hyun Choi, Seok Beom Lee, Junhwa Hong, Honghui Lee, Jinwoo Lee, Joonseok Jang, Juwan Son, Munhyung Bae, Yeo Joon Yoon, Dong-Chan Oh, Suckchang Hong
Published: 202510.1021/acs.orglett.5c04249
Abstract
WS9326B (1) is a cycloheptadepsipeptide isolated from Streptomyces sp. SNM55 and is distinguished by its rare (Z)-pentenyl cinnamic acid side chain and notable antiangiogenic activity. Herein, we report its total synthesis through a bioispired macrol…
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