Organic lettersMethionineHydroxylaminePeptidesMolecular StructureEsters
Chemoselective Methionine Bioconjugation with Hydroxylamine Esters for Peptide/Protein Modifications.
Man Li, Tianyang Wang, Linfeng Chen, Zelin Cui, Aiyun Zuo, Chunyu Wang, Yulin Zhang, Chunrong Liu
Published: 202510.1021/acs.orglett.5c04245
Abstract
Bioconjugation is a powerful strategy and tool to realize the pluripotency of proteins and peptides by allowing access to novel biomolecular scaffolds. Methionine, because of its unique thioether functional group with good nucleophilicity, provides a…
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