Organic lettersDNAMolecular StructureThiocarbamatesAminesEpoxy Compounds
On-DNA Synthesis of 2-Hydroxy Dithiocarbamates.
Yagong Wang, Kehan Zhou, Haiqian Zhu, Huimin Sun, Hongli Cao, Lijun Xue, Kexin Yang, Yun Jin Hu
Published: 202510.1021/acs.orglett.5c04222
Abstract
We present a modular on-DNA bridging strategy that addresses key reactivity challenges in DNA-encoded library synthesis. By generation of a reactive carbamodithioic acid intermediate from secondary amines, this method enables efficient coupling with…
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