Organic letters
Aldehyde Capture Ligation without Involving a Side Chain Functional Group.
Junfeng Zhao, Zhenjia Zhang, Yongsheng Yang, Xiaohong Zhang, Seetharamsing Balamkundu, Chuan-Fa Liu
Published: 202510.1021/acs.orglett.5c04064
Abstract
A potentially general aldehyde capture peptide ligation method was developed. In this method, the salicylaldehyde group in the first ligation partner condenses with the N-terminal amine of the second ligation partner, and an N-hydroxyl elaborately in…
Preview only. Read the full abstract at the source