Organic letters
Regiodivergent Synthesis Utilizing Alkyl Hex-5-en-2-ynoates and 3-Homoacyl Coumarins: Phenol-Mediated Controllable Phosphine-Catalyzed Michael and 1,7-Umpolung Addition.
Ching-Wen Hsu, Yi-Jen Chen, Xuan-Rui Huang, Cheng-Jun Shi, Tzu-I Lin, Tzu-Chun Yen, Yadav Kacharu Nagare, Gangababu Marri, Yi-Ru Chen, Wenwei Lin
Published: 202510.1021/acs.orglett.5c04035
Abstract
We disclose a first example of regiodivergent addition between alkyl hex-5-en-2-ynoates and 3-homoacyl coumarins under phosphine catalysis, in which phenol serves as a decisive additive. This study demonstrates a phenol-mediated switchable pathway be…
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