Organic letters
Hydrosilafluorenes as Recyclable Coupling Reagents for Direct Amidation of Carboxylic Acids with Amines.
Fawwaz Azam, Brigida V Fernandes, Clive A Boateng, Jesse LeBlanc, Alan J Lough, Marc J Adler
Published: 202610.1021/acs.orglett.5c04034
Abstract
We have discovered both 9-methyl- and 9-phenyl-9H-9-silafluorene as effective reagents for direct amidation. The protocol is performed under open-air conditions without rigorous exclusion of moisture, producing amides in high yields with only H2 and…
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