Organic lettersCysteineNitrilesThiazolesPeptidesMolecular Structure
Aqueous Phase Synthesis of Complex Thiazole-Containing Peptides by Condensation of N-Acyl-α-aminonitriles and Cysteine Derivatives.
Shuangshuang Cai, Haiting Ye, Xi Yang, Pengchen Ma, Silong Xu, Yongliang Zhang
Published: 202510.1021/acs.orglett.5c04028
Abstract
The introduction of rigid thiazole motifs into peptide backbones represents a promising strategy to enhance metabolic stability, improve cell permeability, and optimize pharmacokinetic properties. Herein, we report an epimerization-free, one-pot aque…
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