Organic letters
Access to Divergent Indolyl Pyrrolones via [3+2] Annulation of Indolyl Hydroxamates with Phosphonium Ylides.
Xin Tang, Wei Zhang, Dong-Xiao Jiang, Zhang Chen, Lixian Shen, Yao Tian, Jinjin Chen, Zhen Wang, Yao-Fu Zeng
Published: 202510.1021/acs.orglett.5c03964
Abstract
We report a novel [3+2] cycloaddition strategy between indolyl hydroxamates and phosphonium ylides, which selectively constructs three distinct N-heterocycles: indolyl maleimides, 5-methylenepyrrolones, and 5-hydroxypyrrolones. Notably, this work rev…
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