Organic letters
SN2'-Type Difluoro- and Perfluoroalkylation of gem-Dichlorocyclobutenones Mediated by (DMPU)2Zn(Rf)2.
Xujuan Jiang, Bosheng Liu, Cong Li, Xiaohong Wen, Xiaojun Zeng
Published: 202510.1021/acs.orglett.5c03916
Abstract
We report an SN2'-type strategy for direct difluoromethylation and perfluoroalkylation of gem-dichlorocyclobutenones using (DMPU)2Zn(Rf)2 reagents. Difluoromethylation proceeds under metal-free conditions, whereas copper catalyst promotes perfluoroal…
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