Organic letters
Total Synthesis of (±)-Larutienine B and (±)-Melokhanine B, D, E, F, and H.
Yong-Peng Yang, Jingyun Zheng, Jianchao Chen, Lei Ding, Anhua Hu, Jing-Jing Guo
Published: 202510.1021/acs.orglett.5c03815
Abstract
We report a versatile and scalable strategy for the concise syntheses of six C2-spirooxindole alkaloids in 13-15 steps. This synthetic approach features an oxidative aza-Diels-Alder cycloaddition and a retro-Mannich/Mannich reaction to build the tetr…
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