Ring-Opening Reconstruction of Indoles Enabled by C-N Bond Cleavage: Synthesis of Benzo[c]pyrazolo[3,4-h][2,6]naphthyridine Derivatives.

Here we report the iodine-mediated tandem process of indole-ring-opening reconstruction, which accomplishes scaffold hopping from indoles to polycyclic heteroaromatics (PHAs), offering the advantages of simple operation and easily accessible substrat…

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