Organic letters
Mechanistic Insights into Aerobic C(sp3)-H Hydroxylation: A Catalytic Reaction or Not.
Changming Li, Zengwei Wang, Qian Peng
Published: 202510.1021/acs.orglett.5c02510
Abstract
The mechanism of aerobic C(sp3)-H hydroxylation to α-hydroxy ketone is investigated by multiple quantum chemical computations. An alkali-metal-assisted electron transfer (AET) is proposed to drive the triplet-to-singlet transition for C-O bond format…
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