Achieving Efficient Sonopiezoelectric Therapy for Tumor through Electron Spin Modulation via the Chiral-Induced Spin Selectivity Effect.

The recent rise of piezoelectronic technology has revitalized ultrasound-mediated tumor therapy through sonopiezoelectric therapy (SPT). However, piezoelectric semiconductor nanomaterials used as sonocatalysts still face challenges. On the one hand, its sonocatalytic efficiency requires improvement; on the other hand, its catalytic selectivity remains poor. Therefore, enhancing the yield of highly cytotoxic catalytic products is of significant importance. Chiral-Induced Spin Selectivity (CISS) provides a robust foundation for controlling catalytic reaction processes, thereby boosting the yield of highly cytotoxic products. This study pioneers the integration of the CISS effect into sonodynamic tumor therapy, significantly boosting the therapeutic efficacy. Employing R-MBA_MoS2/S-MBA_MoS2/rac-MBA_MoS2 as sonocatalysts, we investigated the enhancement of SPT by chiral molecules. The results demonstrate a significant increase in the yield of ·OH and O2, exhibiting outstanding antitumor efficacy. This phenomenon is attributed to the CISS effect. This study aims to achieve chirality-enhanced sonocatalytic antitumor therapy, opening new avenues for simple and efficient cancer treatment.