Nano lettersUric AcidUrate OxidaseAnimalsDNAMice
A DNA Origami-Based Uricase Nanovehicle for Reducing Blood Uric Acid Levels.
Yi-Shan Liu, Wen-Jia Shi, Hua-Dong Li, Yue Liu, Chao-Qiang Li, Pei-Qiang Ma, Bang-Ce Ye
Published: 202510.1021/acs.nanolett.5c04884
Abstract
Exogenous uricase (UOx) has been employed in hyperuricemia treatment, but its foreign protein nature induces an immunogenicity risk and short circulatory half-life in vivo, limiting clinical application. To address these limitations, we developed a D…
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