Molecular pharmaceutics
Drug-Excipient Interaction-Mediated Supersaturated Emulsion Gel for Enhanced Intradermal Delivery of Tranexamic Acid.
Zhitao Cai, Han Zeng, Zhijie Huang, Yiyao Li, Xiaopeng Deng, Yu Zhang, Tian Yin, Haibing He, Jingxin Gou, Yanjiao Wang, Xing Tang
Published: 202610.1021/acs.molpharmaceut.5c01568
Abstract
The clinical translation of tranexamic acid (TA) for melasma is limited by its hydrophilicity and crystallization tendency, which hinder epidermal drug accumulation in conventional formulations (<5% w/w). We developed a supersaturated emulsion-type g…
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