Molecular pharmaceutics
Molar Dose Optimization for Accurate Pharmacokinetic and Biodistribution Evaluation of FAP-Targeted Radiopharmaceuticals in a Mouse Syngeneic Tumor Model.
Luoxia Liu, Shujie He, Zeyuan Huang, Dongdong Wang, Jianyuan Zhou, Jingfei Yang, Yifan Shi, Zhaoting Cheng, Siyuan Cheng, Sijuan Zou, Jun Zhao, Xiaohua Zhu
Published: 202610.1021/acs.molpharmaceut.5c01553
Abstract
Most studies on fibroblast activated protein (FAP)-targeted radiopharmaceuticals focus on administered radioactivity, often overlooking the impact of a molar dose on tumor-targeting and off-target accumulation. Here, we investigate the effect of mola…
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